With appropriate access to the different and very effective therapies which can only happen if early and correct diagnosis is made, many sequelae will be avoided and lives of patients will be saved.
People with PIDs are normally treated by doctors who specialise in diseases of the immune system. How a patient is treated depends on which PID they have, and on many other factors. Treatments for PIDs include: immunuglobulin (IG) therapies, Hematopoietic Stem Cell Transplantation (BMT), gene therapy, Grantulocyte-colony stimulating factor (G-CSF), Gamma interferon, PEG adenosine deaminase, prophylactic anti-biotics, among others.
In the case of IG therapies it is important to know that different IG products are not interchangeable or mixable. IG can be administered intravenously or subcutaneously. They are considered as essential medicines for PIDs by the World Health Organisation. Intravenous immunoglobulin (IVIG) infusion usually takes 2-4 hours allowing high doses to be given and only needs to be given every 3-4 weeks which may suit some patients better. Subcutaneous immunoglobulin (SCIG) only takes 1-2 hours and can often be given at home by patients themselves, parents or carers. It may therefore be more convenient for some patients. However only small doses can be given by SC infusion, meaning they are given more frequently than IV infusions, usually once a week. A new type of SC infusion containing recombinant human hyaluronidase, known as facilitated subcutaneous immunoglobulin (FSCIG) allows patients to have SC infusions every 3-4 weeks. IG therapy should be chosen on an individualised basis, according to patient needs and preferences.